Delivery of CD47-SIRPα checkpoint blocker by BCMA-directed UCAR-T cells enhances antitumor efficacy in multiple myeloma
Qizhong Lu, Donghui Yang, Hexian Li, Zhixiong Zhu, Zongliang Zhang, Yongdong Chen, Nian Yang, Li Jia, Zeng Wang, Ting Niu, Aiping Tong
Topics & Concepts
CD47Cancer researchMultiple myelomaCD40BiologyImmunologyImmune systemCytotoxic T cellIn vitroBiochemistryCAR-T cell therapy researchImmunotherapy and Immune ResponsesPhagocytosis and Immune Regulation