Modulating lung immune cells by pulmonary delivery of antigen-specific nanoparticles to treat autoimmune disease
Eiji Saito, Stephen J. Gurczynski, Kevin R. Kramer, Carol A. Wilke, Stephen D. Miller, Bethany B. Moore, Lonnie D. Shea
Abstract
T cell proliferation and reduced their population in the central nervous system while increasing them in the lung. This study supports noninvasive pulmonary particle delivery, such as inhalable administration, to treat autoimmune disease.
Topics & Concepts
Immune systemImmunologyAntigenAutoimmune diseaseMedicineLungAntibodyInternal medicineInhalation and Respiratory Drug DeliveryAdvanced Drug Delivery SystemsRNA Interference and Gene Delivery