Hypoxanthine Guanine Phosphoribosyltransferase expression is negatively correlated with immune activity through its regulation of purine synthesis
Michelle H. Townsend, Claudia M. Tellez Freitas, Dallas J. Larsen, Stephen Piccolo, K. Scott Weber, Richard A. Robison, Kim L. O’Neill
Topics & Concepts
Hypoxanthine-guanine phosphoribosyltransferaseImmune systemGene knockdownRaji cellHypoxanthine PhosphoribosyltransferaseChemistryHypoxanthineCancer researchMolecular biologyBiologyCellCell cultureImmunologyBiochemistryEnzymeGeneGeneticsMutantBiochemical and Molecular ResearchFolate and B Vitamins ResearchRNA modifications and cancer