The ESCRT-I Subunit Tsg101 Plays Novel Dual Roles in Entry and Replication of Classical Swine Fever Virus
Chunchun Liu, Yayun Liu, Yan Cheng, Yunna Zhang, Jin Zhang, Xiaodong Liang, Ya Gao, Huan Chen, Abdul Sattar Baloch, Qian Yang, Yun Young Go, Bin Zhou
Abstract
infection remains to be elucidated. We determined the molecular mechanisms of the regulation of CSFV infection by the major subunit Tsg101 of ESCRT-I. Interestingly, Tsg101 plays an essential regulatory role in both clathrin-mediated endocytosis and genome replication of CSFV. Overall, the results of this study provide further insights into the molecular function of ESCRT-I complex protein Tsg101 during CSFV infection, which may serve as a molecular target for pestivirus inhibitors.
Topics & Concepts
BiologyESCRTTSG101VirologyReplication (statistics)Protein subunitViral replicationVirusDual (grammatical number)GeneticsEndosomeGeneReceptorMicrovesiclesArtLiteraturemicroRNAAnimal Disease Management and EpidemiologyViral Infectious Diseases and Gene Expression in InsectsViral Infections and Immunology Research