RNA Phage VLP-Based Vaccine Platforms
David S. Peabody, Julianne Peabody, Steven B. Bradfute, Bryce Chackerian
Abstract
Virus-like particles from a variety of RNA bacteriophages have turned out to be useful platforms for delivery of vaccine antigens in a highly immunogenic format. Here we update the current state of development of RNA phage VLPs as platforms for presentation of diverse antigens by genetic, enzymatic, and chemical display methods.
Topics & Concepts
RNAComputational biologyPhage displayAntigenVirologyBiologyGeneticsGeneAntibodyBacteriophages and microbial interactionsMonoclonal and Polyclonal Antibodies ResearchAdvanced biosensing and bioanalysis techniques