Development of potent inhibitors for strigolactone receptor DWARF 14
Masahiko Yoshimura, Sojung F. Kim, Ryosuke Takise, Shuhei Kusano, Sakuya Nakamura, Masanori Izumi, Akiko Yagi, Kenichiro Itami, Shinya Hagihara
Abstract
Strigolactones (SLs) are plant hormones that suppress shoot branching through perception by their receptor protein DWARF 14 (D14). The artificial regulation of SL signaling has been considered a potent agricultural technique because plant architecture is strongly related to crop yield. In this communication, we describe the development of a small-molecule D14 inhibitor that functions at sub-micromolar levels. This potent inhibitor may be a lead compound for a first-in-class plant growth regulator.
Topics & Concepts
StrigolactoneReceptorShootChemistryBranching (polymer chemistry)HormoneSmall moleculeStereochemistryBiologyBiochemistryBotanyArabidopsisOrganic chemistryGeneMutantPlant Parasitism and ResistancePlant and animal studiesPlant Molecular Biology Research