In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma
Juan Dubrot, Sarah Kate Lane-Reticker, Emily Kessler, Austin Ayer, Gargi Mishra, Clara Wolfe, Margaret D. Zimmer, Peter P. Du, Animesh Mahapatra, Kyle Ockerman, Thomas Davis, Ian C. Kohnle, Hans W. Pope, Peter M. Allen, Kira E. Olander, Arvin Iracheta‐Vellve, John G. Doench, W. Nicholas Haining, Kathleen B. Yates, Robert T. Manguso
Topics & Concepts
CRISPRBiologyImmune systemMajor histocompatibility complexGenome editingCancer researchIn vivoCas9Viral vectorImmunotherapyImmunologyGeneticsGeneRecombinant DNACRISPR and Genetic EngineeringCAR-T cell therapy research