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In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma

Juan Dubrot, Sarah Kate Lane-Reticker, Emily Kessler, Austin Ayer, Gargi Mishra, Clara Wolfe, Margaret D. Zimmer, Peter P. Du, Animesh Mahapatra, Kyle Ockerman, Thomas Davis, Ian C. Kohnle, Hans W. Pope, Peter M. Allen, Kira E. Olander, Arvin Iracheta‐Vellve, John G. Doench, W. Nicholas Haining, Kathleen B. Yates, Robert T. Manguso

2021Immunity93 citationsDOIOpen Access PDF

Topics & Concepts

CRISPRBiologyImmune systemMajor histocompatibility complexGenome editingCancer researchIn vivoCas9Viral vectorImmunotherapyImmunologyGeneticsGeneRecombinant DNACRISPR and Genetic EngineeringCAR-T cell therapy research
In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma | Litcius