Discovery of a potent and selective allosteric inhibitor targeting the SHP2 tunnel site for RTK-driven cancer treatment
Ruixiang Luo, Weitao Fu, Jingjing Shao, Lin Ma, Sujuan Shuai, Ying Xu, Zheng Jiang, Zenghui Ye, Lulu Zheng, Lei Zheng, Jie Yu, Yawen Zhang, Lina Yin, Linglan Tu, Xinting Lv, Jie Li, Guang Liang, Lingfeng Chen
Topics & Concepts
Allosteric regulationChemistryReceptor tyrosine kinaseProtein tyrosine phosphataseProto-oncogene tyrosine-protein kinase SrcKinaseAllosteric modulatorPhosphataseCancer researchPharmacologyBiochemistryReceptorPhosphorylationBiologyProtein Tyrosine PhosphatasesGalectins and Cancer BiologyBioactive Compounds and Antitumor Agents