Design, synthesis, and pharmacological evaluation of 4- or 6-phenyl-pyrimidine derivatives as novel and selective Janus kinase 3 inhibitors
Lei Shu, Chengjuan Chen, Xueting Huan, Hao Huang, Manman Wang, Jianqiu Zhang, Yile Yan, Jianming Liu, Tiantai Zhang, Dayong Zhang
Topics & Concepts
ChemistryJanus kinaseIn vivoPharmacologyTyrosine kinaseKinaseCytokineSignal transductionBiochemistryImmunologyBiologyBiotechnologyCytokine Signaling Pathways and InteractionsPharmacological Effects of Natural CompoundsPhytochemistry and Bioactive Compounds