Engineering Dynamic Defect of Ce<sup>III</sup>/Ce<sup>IV</sup>‐Based Metal‐Organic Framework through Ultrasound‐Triggered Au Electron Trapper for Sonodynamic Therapy of Osteomyelitis
Qiyao Zheng, Xiangmei Liu, Song Gao, Zhenduo Cui, Shuilin Wu, Yanqin Liang, Zhaoyang Li, Yufeng Zheng, Shengli Zhu, Hui Jiang, Ruqiang Zou
Abstract
Abstract Defect engineering is an important way to tune the catalytic properties of metal‐organic framework (MOF), yet precise control of defects is difficult to achieve. Herein, a cerium‐based MOF (CeTCPP) is decorated with Au nanoparticles. Under ultrasound irradiation, Au nanoparticles can precisely turn 1/3 of the pristine Ce 3+ nodes into Ce 4+ . With the stable existence of Ce 4+ , the coordination of Ce nodes changed, causing the structural irregularity in CeTCPP‐Au, so that the electron‐hole recombination is obviously hindered, facilitating the generation of reactive oxygen species. Therefore, under 20 min of ultrasound irradiation, the CeTCPP‐Au showed superior antibacterial efficacy of over 99% against Staphylococcus aureus and Escherichia coli with good biocompatibility, which is further used for effective therapy of osteomyelitis. Overall, this work provides a dynamic defect formation strategy of MOF through the electron trapping of Au nanoparticles, which also sheds light on sonodynamic therapy in curing deep‐seated lesions.