Morpholine substituted quinazoline derivatives as anticancer agents against MCF-7, A549 and SHSY-5Y cancer cell lines and mechanistic studies
Ashish Ranjan Dwivedi, Vijay Kumar, Vijay Kumar, Vikash Prashar, Akash Verma, Naveen Kumar, Jyoti Parkash, Vinod Kumar, Vinod Kumar
Abstract
inhibit the cell proliferation in the G1 phase of the cell cycle and the primary cause of death of the cells was found to be through apoptosis. Thus, morpholine based quinazoline derivatives have the potential to be developed as potent anticancer drug molecules.
Topics & Concepts
MorpholineQuinazolineChemistryCancer cellMCF-7Cytotoxic T cellCell cultureApoptosisA549 cellCell cycleCytotoxicityCancerIn vitroCancer researchBiochemistryCombinatorial chemistryBiologyHuman breastMedicinal chemistryGeneticsQuinazolinone synthesis and applicationsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activity