Dual-action gallium-flavonoid compounds for combating<i>Pseudomonas aeruginosa</i>infection
Xiaojun He, Bingjie Han, Runming Wang, Yu Guo, Richard Yi Tsun Kao, Hongyan Li, Hongzhe Sun, Wei Xia
Abstract
A gallium compound shows strong antibacterial effects against Pseudomonas aeruginosa while being low in cytotoxicity. It eradicates the pathogen by targeting quorum sensing and iron metabolism pathways, making it a “dual-action” antibacterial agent.
Topics & Concepts
Pseudomonas aeruginosaQuorum sensingBiofilmMicrobiologyVirulenceGalliumImmune systemBacteriaBiologyAntibioticsPathogenAntimicrobialHuman pathogenGeneChemistryBiochemistryImmunologyGeneticsOrganic chemistryBacterial biofilms and quorum sensingAntimicrobial Peptides and ActivitiesAntibiotic Resistance in Bacteria