Lipid peroxidation biomarkers associated with height and obesity measures in the opposite direction in women
Mengjie Li, Yingya Zhao, Qi Dai, Ginger L. Milne, Jirong Long, Qiuyin Cai, Qingxia Chen, Xianglan Zhang, Qing Lan, Nathaniel Rothman, Yu‐Tang Gao, Xiao‐Ou Shu, Wei Zheng, Gong Yang
Abstract
Abstract Objective This study aimed to investigate whether and how lipid peroxidation markers are associated with height and obesity measures. Methods In two independent samples of women (Study 1: n = 1,005; Study 2: n = 1,158), systemic levels of lipid peroxidation were assessed by urinary markers F 2 ‐isoprostanes (F 2 ‐IsoPs) and its major metabolite (F 2 ‐IsoP‐M), with gas chromatography/negative ion chemical ionization mass spectrometry assays. Anthropometric parameters were directly measured and genetically estimated, and they were used in the primary analysis and in a Mendelian randomization analysis in relation to lipid peroxidation, respectively, with general linear models. Results After adjusting for potential confounders, it was found that measured adult height was inversely associated with levels of F 2 ‐IsoPs ( β = −0.89, p < 0.001) and F 2 ‐IsoP‐M ( β = −0.71, p = 0.003), whereas obesity measures were positively associated with F 2 ‐IsoP‐M ( β = 1.81, p < 0.001 for BMI; and β = 0.77, p < 0.001 for waist circumference). Results were consistent between the two study samples. The opposite associations were further replicated when using genetically determined measures of height and obesity in the Mendelian randomization analysis. Moreover, analyses mutually adjusted for height and obesity measures suggested that these associations were independent of one another. Conclusions This study, for the first time, to our knowledge, reveals that a shared biological process (lipid peroxidation) is associated with both height and obesity measures but in the opposite direction.