Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration<i>via</i>antioxidant enzymes and SIRT1/ADAM10 signaling pathway
Naw Hser Gay, Wilasinee Suwanjang, Waralee Ruankham, Napat Songtawee, Prapimpun Wongchitrat, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin
Abstract
treatment compared to cells without pretreatment and the reference (resveratrol). Molecular docking analysis revealed that the interactions between the activator-binding sites of SIRT1 and the phenolic compounds were similar to those of resveratrol. Taken together, the data suggest that these polyphenolic compounds could be potential candidates for prevention and/or treatment of neurodegeneration.
Topics & Concepts
ScopoletinIsoliquiritigeninChemistryNeurodegenerationProgrammed cell deathReactive oxygen speciesBiochemistryAntioxidantOxidative stressPharmacologyResveratrolNeuroprotectionApoptosisBiologyMedicineInternal medicineAlternative medicinePathologyDiseasePharmacological Effects of Natural CompoundsSirtuins and Resveratrol in MedicineGinseng Biological Effects and Applications