Photoinduced radical cascade domino Heck coupling of <i>N</i>-aryl acrylamide with vinyl arenes enabled by palladium catalysis
Pei-Shang Li, Qiaoqiao Teng, Ming Chen
Abstract
an open-shell intermediate and occurs under mild reaction conditions, exhibiting excellent functional group tolerance. Importantly, the synthesized products can be readily transformed into biologically active molecules, including (±)-physostigmine and (±)-physovenine.
Topics & Concepts
Heck reactionPalladiumArylCascade reactionChemistryCatalysisDominoFunctional groupCombinatorial chemistryCascadeAcrylamidePhotochemistryCoupling reactionOrganic chemistryAlkylCopolymerPolymerChromatographyCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques