Treatment-emergent cefiderocol resistance in carbapenem-resistant <i>Acinetobacter baumannii</i> is associated with insertion sequence IS <i>Aba36</i> in the siderophore receptor <i>pirA</i>
En Huang, Rebekah N. Thompson, Sun Hee Moon, Jacob M. Keck, Michael S. Lowry, Joe Melero, Se‐Ran Jun, Eric Rosenbaum, Ryan K Dare
Abstract
ABSTRACT We report the emergence of cefiderocol resistance in a bla OXA-72 carbapenem-resistant Acinetobacter baumannii isolate from a sacral decubitus ulcer. Cefiderocol was initially used; however, a newly approved sulbactam-durlobactam therapy with source control and flap coverage was successful in treating the infection. Laboratory investigation revealed cefiderocol resistance mediated by IS Aba36 insertion into the siderophore receptor pirA .
Topics & Concepts
SiderophoreAcinetobacter baumanniiAcinetobacterMicrobiologyBiologyPseudomonas aeruginosaCarbapenemBacteriaAntibioticsGeneticsAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyPlant Pathogenic Bacteria Studies