Enantioselective decarboxylative Mannich reaction of β-keto acids with <i>C</i>-alkynyl <i>N</i>-Boc <i>N</i>,<i>O</i>-acetals: access to chiral β-keto propargylamines
Congcong Zhang, Lijun Chen, Baochun Shen, Huiding Xie, Wei Li, Zhongwen Sun
Abstract
The first asymmetric Mannich reaction of C -alkynyl N -Boc N , O -acetals with β-ketoacids has been developed to access chiral β-keto propargylamines.
Topics & Concepts
Enantioselective synthesisChemistryMannich reactionMedicinal chemistryCombinatorial chemistryOrganic chemistryCatalysisAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry MethodsSynthesis and Catalytic Reactions