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Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

Tobias Baumann, Andreas Dunkel, Christian Schmid, Sabine Schmitt, Michael Hiltensperger, Kerstin Lohr, Vibor Laketa, Sainitin Donakonda, Uwe Ahting, Bettina Lorenz‐Depiereux, Jan E. Heil, Johann Schredelseker, Luca Simeoni, Caroline Fecher, Nina Körber, Tanja Bauer, Norbert Hüser, Daniel Hartmann, Melanie Laschinger, Kilian Eyerich, Stefanie Eyerich, Martina Anton, Matthew D. Streeter, Tina Wang, Burkhart Schraven, David A. Spiegel, Farhah F. Assaad, Thomas Misgeld, Hans Zischka, Peter J. Murray, Annkristin Heine, Mathias Heikenwälder, Thomas Korn, Corinna Dawid, Thomas Hofmann, Percy A. Knolle, Bastian Höchst

2020Nature Immunology215 citationsDOIOpen Access PDF

Topics & Concepts

Immune systemMethylglyoxalCytotoxic T cellMyeloid-derived Suppressor CellCancer cellCancer researchAdoptive cell transferT cellCD8BiologyTumor microenvironmentEffectorCell biologyCancerChemistryImmunologySuppressorBiochemistryIn vitroGeneticsEnzymeImmune cells in cancerImmune Cell Function and InteractionNeutrophil, Myeloperoxidase and Oxidative Mechanisms
Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal | Litcius