Most-Probable-Number-Based Minimum Duration of Killing Assay for Determining the Spectrum of Rifampicin Susceptibility in Clinical Mycobacterium tuberculosis Isolates
Srinivasan Vijay, Hoang Ngoc Nhung, Nguyen Le Hoai Bao, Do Dang Anh Thu, Le Pham Tien Trieu, Nguyen Hoan Phu, Guy Thwaites, Babak Javid, Nguyễn Thụy Thương Thương
Abstract
Accurate antibiotic susceptibility testing is essential for successful tuberculosis treatment. Recent studies have highlighted the limitations of MIC-based phenotypic susceptibility methods in detecting other aspects of antibiotic susceptibilities in bacteria. Duration and peak of antibiotic exposure, at or above the MIC required for killing the bacterial population, has emerged as another important factor for determining antibiotic susceptibility. This is broadly defined as antibiotic tolerance.
Topics & Concepts
RifampicinAntibioticsMycobacterium tuberculosisTuberculosisMicrobiologyPopulationBiologyAntibacterial agentMedicinePathologyEnvironmental healthMycobacterium research and diagnosisTuberculosis Research and EpidemiologyAntibiotic Resistance in Bacteria