MGP Promotes Colon Cancer Proliferation by Activating the NF-κB Pathway through Upregulation of the Calcium Signaling Pathway
Xueqing Li, Rui Wei, Mizhu Wang, Li Ma, Zheng Zhang, Lei Chen, Qingdong Guo, Shuilong Guo, Shengtao Zhu, Shutian Zhang, Li Min
Abstract
concentration and the subsequent growth inhibition effect on CC cells induced by small interfering RNA targeting MGP (siMGP) could be rescued by a higher calcium concentration environment. Therefore, MGP promotes the growth and proliferation of CC cells by enriching intracellular calcium concentration and activating the NF-κB pathway, and it could serve as a potential prognostic biomarker in CC patients.
Topics & Concepts
Downregulation and upregulationSignal transductionNF-κBColorectal cancerCancer researchCalciumCell biologyChemistryCancerBiologyMedicineInternal medicineBiochemistryGeneSignaling Pathways in DiseaseGalectins and Cancer BiologyMuscle Physiology and Disorders