Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin
David Townsend, Nigel J. Fullwood, Edwin A. Yates, David A. Middleton
Abstract
-sulfate is removed. These findings may have implications for the progression of AD, as the sulfation pattern of GAGs is known to change during the aging process, which is the main risk factor for the disease.
Topics & Concepts
ChemistrySulfationBiophysicsHeparinHeparan sulfateCircular dichroismKineticsTau proteinGlycosaminoglycanBiochemistryStereochemistryBiologyAlzheimer's diseaseQuantum mechanicsDiseasePathologyMedicinePhysicsProteoglycans and glycosaminoglycans researchGlycosylation and Glycoproteins ResearchProtein Structure and Dynamics