The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
Nicole E. Scharping, Ashley V. Menk, Rebecca S. Moreci, Ryan D. Whetstone, Rebekah Dadey, Simon C. Watkins, Robert L. Ferris, Greg M. Delgoffe
Topics & Concepts
Tumor microenvironmentBiologyMitochondrial biogenesisCancer researchTumor progressionCell biologyReprogrammingCancer cellT cellCancerMitochondrionCellImmunologyTumor cellsBiochemistryImmune systemGeneticsImmune cells in cancerImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers