Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax
Hannah M. King, Sandeep Rana, Sydney P. Kubica, Jayapal Reddy Mallareddy, Smitha Kizhake, Edward L. Ezell, Muhammad Zahid, Michael J. Naldrett, Sophie Alvarez, Henry C.-H. Law, Nicholas T. Woods, Amarnath Natarajan
Topics & Concepts
KinomeChemistryCancer researchCyclin-dependent kinaseKinasePancreatic cancerSynthetic lethalityCyclin-dependent kinase 9Protein kinase ACancerGeneBiochemistryCyclin-dependent kinase 2Cell cycleBiologyGeneticsMutantProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis