Hypochlorous acid-activated two-photon fluorescent probe for evaluation of anticancer drug-induced cardiotoxicity and screening of antioxidant drugs
Kaiqiang Liu, Jian Zhang, Xinxin Li, Yingying Xie, Yong Li, Xu Wang, Xiaoyun Jiao, Xilei Xie, Bo Tang
Abstract
THPIC was developed to detect HClO in lysosomes. The results showed that HClO could be used as a biomarker for evaluating drug-induced cardiotoxicity, and THPIC could be applied as a platform for screening drugs to prevent cardiotoxicitys.
Topics & Concepts
CardiotoxicityChemistryHypochlorous acidDrugAntioxidantPharmacologyFluorescenceBiomarkerBiochemistryToxicityOrganic chemistryMedicinePhysicsQuantum mechanicsAnalytical Chemistry and SensorsElectrochemical sensors and biosensorsMolecular Sensors and Ion Detection