A sustainable one-pot method to transform seashell waste calcium carbonate to osteoinductive hydroxyapatite micro-nanoparticles
Raquel Fernández-Penas, Cristóbal Verdugo‐Escamilla, Carla Triunfo, Stefanie Gärtner, Annarita D’Urso, Francesca Oltolina, Antonia Follenzi, Gabriele Maoloni, Helmut Cölfen, Giuseppe Falini, Jaime Gómez‐Morales
Abstract
a dissolution-reprecipitation mechanism driven by the favorable balance between HA precipitation and bCCP dissolution, due to the lower solubility product of HA than that of calcite at any of the tested temperatures. Both the bCCP and the derived HA particles were cytocompatible for MG-63 human osteosarcoma cells and m17.ASC murine mesenchymal stem cells, and additionally, they promoted the osteogenic differentiation of m17.ASC, especially the HA particles. Because of their physicochemical features and biological compatibility, both particles could be useful osteoinductive platforms for translational applications in bone tissue engineering.