Design, green synthesis, and quorum sensing quenching potential of novel 2-oxo-pyridines containing a thiophene/furan scaffold and targeting a <i>Las</i>R gene on <i>P. aeruginosa</i>
Yousry A. Ammar, Ahmed Ragab, M.A. Migahed, S. Al-Sharbasy, Mohamed A. Salem, Omnia Karem M. Riad, Heba Mohammed Refat M. Selim, Gehad A. Abd-elmaksoud, Moustafa S. Abusaif
Abstract
R and predicted the key binding interactions responsible for the activity that corroborated the biological results.
Topics & Concepts
Quorum sensingChemistryMinimum bactericidal concentrationBiofilmPotencyMinimum inhibitory concentrationVirulenceAntimicrobialCandida albicansGentamicinMicrobiologyThiopheneCorpus albicansAntibacterial activityIC50BacteriaStereochemistryNuclear chemistryAntibioticsBiologyOrganic chemistryBiochemistryGeneIn vitroGeneticsBacterial biofilms and quorum sensingAntimicrobial Peptides and ActivitiesAntimicrobial Resistance in Staphylococcus