Novel indazole derivatives as potent apoptotic antiproliferative agents by multi-targeted mechanism: Synthesis and biological evaluation
Firas Obaid Arhema Frejat, Hongjin Zhai, Yaquan Cao, Lihong V. Wang, Yaser A. Mostafa, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Chunli Wu
Topics & Concepts
IndazoleChemistryMoietyDoxorubicinApoptosisCell cultureCytotoxicityMTT assayCell growthBiological activityStereochemistryCombinatorial chemistryIn vitroBiochemistryChemotherapyBiologyMedicineSurgeryGeneticsSynthesis and biological activityQuinazolinone synthesis and applicationsCancer therapeutics and mechanisms