<i>CTNNB1/</i> β <i>-catenin</i> dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes
Maopei Chen, Peng Lu, Qinyun Ma, Yanan Cao, Na Chen, Wen Li, Shaoqian Zhao, Banru Chen, Juan Shi, Yingkai Sun, Hong‐Bin Shen, Liangdan Sun, Juan Shen, Qijun Liao, Yifei Zhang, Jie Hong, Weiqiong Gu, Ruixin Liu, Guang Ning, Weiqing Wang, Jiqiu Wang
Abstract
), an adipocyte-derived chemokine, through β-catenin-TCF (T-Cell-Specific Transcription Factor) complex in mature adipocytes, and Saa3 activated macrophages to secrete several factors, including Pdgf-aa, which further promoted the proliferation of preadipocytes, suggesting that β-catenin/Saa3/macrophages may mediate mature adipocyte-preadipocyte cross-talk and fat expansion in sWAT. The identification of β-catenin as a key regulator in fat expansion and human adiposity provides the basis for developing drugs targeting Wnt/β-catenin pathway to combat obesity.