Tumor immune evasion arises through loss of TNF sensitivity
Conor J. Kearney, Stephin J. Vervoort, Simon J. Hogg, Kelly M. Ramsbottom, Andrew J. Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin Brown, Deborah A. Knight, Vivien R. Sutton, Paul A. Beavis, Ilia Voskoboinik, Phillip K. Darcy, John Silke, Joseph A. Trapani, Ricky W. Johnstone, Jane Oliaro
Abstract
T cell- and NK cell-mediated killing of tumor cells, our study also provides a comprehensive picture of the roles of the TNF, IFN, and antigen presentation pathways in immune-mediated tumor surveillance.
Topics & Concepts
Evasion (ethics)Immune systemTumor necrosis factor alphaBiologyCRISPRImmunologyMechanism (biology)Immune surveillanceMicrobiologyGeneGeneticsEpistemologyPhilosophyImmune Cell Function and InteractionCancer Immunotherapy and BiomarkersT-cell and B-cell Immunology