N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure–activity relationships and X-ray crystallographic studies
Minglei Li, Shengjie Liu, Hui Chen, Xinyu Zhou, Jin Zhou, Shuxi Zhou, Haoliang Yuan, Qing‐Long Xu, Jun Liu, Keguang Cheng, Hongbin Sun, Yue Wang, Caiping Chen, Xiaoan Wen
Topics & Concepts
ChemistryLNCaPIC50Deubiquitinating enzymeStereochemistryCrystal structureStructure–activity relationshipCell growthUbiquitinEnzymeIn vitroBiochemistryCrystallographyCancer cellGeneCancerInternal medicineMedicineUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysGenetics and Neurodevelopmental Disorders