Leishmania donovani Metacyclic Promastigotes Impair Phagosome Properties in Inflammatory Monocytes
Christine Matte, Guillermo Arango Duque, Albert Descoteaux
Abstract
from the PV membrane. Moreover, we observed that unlike phagosomes enclosing zymosan particles, vacuoles containing parasites acidify poorly. Interestingly, whereas the parasite surface coat virulence glycolipid lipophosphoglycan (LPG) was responsible for the inhibition of PV acidification, impairment of the NADPH oxidase assembly was independent of LPG and GP63. Collectively, these observations indicate that permissiveness of inflammatory monocytes to L. donovani may thus be related to the ability of this parasite to impair the microbicidal properties of phagosomes.
Topics & Concepts
Leishmania donovaniBiologyMicrobiologyPhagosomeLipophosphoglycanLeishmaniaNADPH oxidaseLeishmania majorVacuoleLeishmania mexicanaImmunologyPhagocytosisLeishmaniasisVisceral leishmaniasisParasite hostingCell biologyReactive oxygen speciesCytoplasmWorld Wide WebComputer scienceResearch on Leishmaniasis StudiesParasites and Host InteractionsTrypanosoma species research and implications