Women with preeclampsia may have reduced risk of breast cancer: a meta-analysis of cohort studies with 7.8 million participants
Min Yao, Lijie Chen, Puchao Peng, Zhiwei Zhong
Abstract
= 50%). Follow-up ranged from 8 to 29.2 years. Results did not change during sensitivity analysis. Outcomes varied on subgroup analysis based on location, study type, data extraction method, incidence of breast cancer, and follow-up. To conclude, women with PE may have a reduced risk of breast cancer later in life. However, the risk reduction is minimal and may not have much clinical significance. The evidence is also limited by high inter-study heterogeneity and lack of adjustment of all possible confounders.
Topics & Concepts
MedicineBreast cancerMeta-analysisCohort studyConfoundingSubgroup analysisIncidence (geometry)Internal medicineRelative riskPublication biasObstetricsCohortOncologyCancerGynecologyConfidence intervalPhysicsOpticsPregnancy and preeclampsia studiesBirth, Development, and HealthCancer Risks and Factors