Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy
Kairui Feng, Feng Wang, Xin‐Wei Shi, Yun‐Xuan Tan, Jiaying Zhao, Jianwei Zhang, Qinghua Li, Guo‐Qiang Lin, Dingding Gao, Ping Tian
Topics & Concepts
STAT3ChemistrySTAT proteinIn vivoApoptosisIC50Cancer researchCell growthSH2 domainActivator (genetics)Docking (animal)Cancer cellIn vitroCancerSignal transductionPharmacologyBiochemistryReceptorBiologyProto-oncogene tyrosine-protein kinase SrcInternal medicineMedicineBiotechnologyNursingCytokine Signaling Pathways and InteractionsCancer Mechanisms and TherapyProtein Tyrosine Phosphatases