Polymorphism, Nanostructures, and Barrier Properties of Ceramide-Based Lipid Films
Petra Pullmannová, Barbora Amélie Čuříková-Kindlová, Veronika Ondrejčeková, Andrej Kováčik, Kristýna Dvořáková, Lucia Dulanská, R. Georgii, Adam Majcher, J. Maixner, Norbert Kučerka, Jarmila Zbytovská, Kateřina Vávrová
Abstract
= 10.63-10.78 nm) depending on the annealing conditions. The proposed molecular arrangement of the MLP based on extended Cer molecules also agreed with the relative neutron scattering length density profiles obtained from the neutron diffraction data. The presence of MLP increased the lipid film permeability to the lipophilic model permeant (indomethacin) relative to the CerNS24-based control samples and the samples that had the same lipid composition but formed an SLP. Thus, the arrangement of lipids in various nanostructures is responsive to external conditions during sample preparation. This polymorphic behavior directly affects the barrier properties, which could also be (patho)physiologically relevant.