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ERK–USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth

Jingjing Tao, Zheng Wang, Rongkai Shi, Liming Lin, Min Li, Ying Meng, Shudi Luo, Xiaoming Jiang, Zhanpeng Guo, Yongfeng Shang, Zhimin Lu

2025Nature Structural & Molecular Biology8 citationsDOI

Topics & Concepts

EnzymeMAPK/ERK pathwayKinaseChemistryEnzyme activatorEnzyme assayCell biologyThymidineBiochemistryBiologyDNAUbiquitin and proteasome pathwaysCancer, Hypoxia, and MetabolismHistone Deacetylase Inhibitors Research
ERK–USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth | Litcius