Integrated bioinformatic analysis reveals the underlying molecular mechanism of and potential drugs for pulmonary arterial hypertension
Haoru Dong, Xiuchun Li, Mengsi Cai, Chi Zhang, Weiqi Mao, Ying Wang, Qian Xu, Mayun Chen, Liangxing Wang, Xiaoying Huang
Abstract
. Together, these analyses principally identified CSF3R, NT5E, ANGPT2, FGF7 and CXCL9 as candidate biomarkers of PAH, and ruxolitinib might exert promising therapeutic action for PAH.
Topics & Concepts
RuxolitinibPharmacologyMechanism (biology)Mechanism of actionKEGGMedicineGeneComputational biologyBiologyInternal medicineIn vitroTranscriptomeBiochemistryGene expressionBone marrowMyelofibrosisEpistemologyPhilosophyPulmonary Hypertension Research and TreatmentsPI3K/AKT/mTOR signaling in cancerCircular RNAs in diseases