A natural polymer-based hydrogel with shape controllability and high toughness and its application to efficient osteochondral regeneration
Jueying Yang, Hui Wang, Weiting Huang, Kelin Peng, Rui Shi, Wei Tian, Lizhi Lin, Jingjing Yuan, Weishang Yao, Xilan Ma, Yu Chen
Abstract
experiments. Furthermore, the adaptability for irregular defects, suitable toughness, adhesive properties, and degradability of PEMN hydrogels are beneficial to provide mechanical support, induce endogenous cell mineralization, and accelerate the regeneration of cartilage and subchondral bone with more than 40% bone regeneration in 12 weeks. Our work has provided a novel solution to simultaneously achieve shape controllability and high toughness based on natural polymers among the already well-explored strategies for osteochondral regeneration.
Topics & Concepts
ControllabilityRegeneration (biology)ToughnessMaterials sciencePolymerComposite materialMathematicsBiologyCell biologyApplied mathematicsHydrogels: synthesis, properties, applicationsSilk-based biomaterials and applications3D Printing in Biomedical Research