Oral nanotherapeutics with enhanced mucus penetration and ROS-responsive drug release capacities for delivery of curcumin to colitis tissues
Yamei Huang, Brandon S.B. Canup, Shuangquan Gou, Nanxi Chen, Fangyin Dai, Bo Xiao, Chang Ming Li
Abstract
-rich environment. Additionally, P-CUR/CAT-NPs showed the strongest capacity to suppress the secretion of the main pro-inflammatory cytokines, in comparison with their counterparts (CUR-NPs and P-CUR-NPs). Importantly, oral administration of P-CAT/CUR-NPs showed the best therapeutic outcomes than the other NPs. Collectively, these results clearly demonstrate that these mucus-penetrating NPs loaded with CAT and CUR can be exploited as an efficient nanotherapeutic for UC therapy.
Topics & Concepts
MucusCurcuminPenetration (warfare)Drug deliveryDrugPharmacologyColitisNanotechnologyMaterials scienceMedicineImmunologyBiologyOperations researchEngineeringEcologyAdvanced Drug Delivery SystemsCurcumin's Biomedical ApplicationsAdvancements in Transdermal Drug Delivery