The immunomodulatory role of Regnase family RNA-binding proteins
Maximilian Fischer, Tobias Weinberger, Christian Schulz
Abstract
RNA-binding proteins regulate RNA fate and govern post-transcriptional gene regulation. A new family of RNA-binding proteins is represented by regulatory RNases (Regnase, also known as Zc3h12 or MCPIP), which have emerged as important players in immune homoeostasis. Four members, Regnase1-4, have been identified to date. Here we summarize recent findings on the role of Regnase in the regulation of RNA biology and its consequences for cell functions and inflammatory processes.
Topics & Concepts
BiologyRNA-binding proteinRNAGeneticsRegulation of gene expressionCell biologyRiboswitchPlasma protein bindingGeneComputational biologyNon-coding RNARNA Research and SplicingRNA modifications and cancerRNA regulation and disease