Litcius/Paper detail

Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial

Jeanne Tie, Yuxuan Wang, Jonathan M. Loree, Joshua D. Cohen, Rachel Wong, Timothy Price, Niall C. Tebbutt, Val Gebski, David Espinoza, Matthew Burge, Sam Harris, James Lynam, Belinda Lee, Margaret M. Lee, Daniel Breadner, Marlyse A. Debrincat, Siavash Foroughi, Lorraine A. Chantrill, Stephanie Lim, Sharlene Gill, Chris O’Callaghan, Janine Ptak, Natalie Silliman, Lisa Dobbyn, Maria Popoli, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Peter Gibbs, AGITG DYNAMIC-III Study Group (Intergroup Study of the Australasian Gastro-Intestinal Trials Group and Canadian Cancer Trials Group), Australasia Gastro-Intestinal Trials Group, Sue‐Anne McLachlan, Madhu Singh, Theresa Hayes, Joanne Lundy, Zee Wan Wong, Geoff Chong, Ayesha Saqib, Simone Steel, Morteza Aghmesheh, Stephen Begbie, Aflah Roohullah, Philip Beale, Weng Ng, Connie I. Diakos, Ratnesh Kumar Srivastav, Sunil Rai, Matt Wong, Deme Karikios, Megan Barnett, Caroline Lum, Craig Underhill, Pirooz Poursoltan, Bhaskar Karki, Christos S. Karapetis, Timothy Price, Adnan Khattak, Melanie Wuttke, Narayan Karanth, Mark Jeffery, Canadian Cancer Trials Group, Radhika Yelamanchili, Anupam Batra, Daryl Roitman, Joanna Gotfrit, Iqbal Mussawar, Shaqil Kassam, John R. Goffin, Sara Rask, Stacey Hubay, Eric X. Chen, Setareh Samimi, Samuel Martel, Urszula Zurawska, Ralph Wong, Lucas Sidéris, Patricia A. Tang, John Paul McGhie, Saroosh Arif, Shahid Ahmed, James Michael, Katharine Shim, Sam Babak, Dawn Elizabeth Armstrong, R. Burkes, Petr Kavan

2025Nature Medicine40 citationsDOI

Topics & Concepts

MedicineOxaliplatinInternal medicineColorectal cancerOncologyCirculating tumor DNAClinical endpointChemotherapyAdjuvantStage (stratigraphy)Adjuvant chemotherapyRandomized controlled trialAdverse effectAdjuvant therapyClinical trialConfidence intervalExploratory analysisSurrogate endpointFluorouracilPhases of clinical researchCancerSurgeryProspective cohort studyOverall survivalProportional hazards modelGastroenterologyProgression-free survivalCancer Genomics and DiagnosticsGenetic factors in colorectal cancerColorectal Cancer Treatments and Studies