New insights into the anticancer effects of Polycladia crinita aqueous extract and its selenium nanoformulation against the solid Ehrlich carcinoma model in mice via VEGF, notch 1, NF-кB, cyclin D1, and caspase 3 signaling pathway
Badriyah S. Alotaibi, Thanaa A. El‐Masry, Hend Mostafa Selim, Maisra M. El‐Bouseary, Mostafa M. El‐Sheekh, Mofida E. M. Makhlof, Maysa M. F. El‐Nagar
Abstract
The PCSeNPs mediated their promising anti-cancerous action by enhancing apoptosis and mitigating inflammation, which manifested in promoting the total survival rate and the tumor volume decrease.
Topics & Concepts
Cyclin D1VEGF receptorsSeleniumNotch signaling pathwayChemistryCancer researchPharmacologyNF-κBCell biologyCell cycleApoptosisMedicineBiologySignal transductionBiochemistryOrganic chemistrySeaweed-derived Bioactive CompoundsBioactive Compounds and Antitumor AgentsAlgal biology and biofuel production