Copper-Catalyzed Regio- and Stereoselective Three-Component Coupling of Allenyl Ethers with <i>gem</i>-Dichlorocyclobutenones and B<sub>2</sub>pin<sub>2</sub>
Shuai Liu, Yi-Sen Qian, Jian‐Lin Xu, Lei Xu, Yun‐He Xu
Abstract
The three-component coupling method for regio- and stereoselective difunctionalization of allenes with allenyl ethers, bis(pinacolato)diboron, and gem -dichlorocyclobutenones as electrophiles was reported, yielding a variety of highly functionalized cyclobutenone products tethering with an alkenylborate fragment. The polysubstituted cyclobutenone products also underwent diverse transformations.
Topics & Concepts
StereoselectivityChemistryElectrophileCatalysisComponent (thermodynamics)RegioselectivityCoupling (piping)CopperCombinatorial chemistryStereochemistryOrganic chemistryMedicinal chemistryPhysicsMechanical engineeringEngineeringThermodynamicsOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods