Autoantibody profiling identifies predictive biomarkers of response to anti-PD1 therapy in cancer patients
Qiaoyun Tan, Dan Wang, Jianliang Yang, Puyuan Xing, Sheng Yang, Yang Li, Yan Qin, Xiaohui He, Yutao Liu, Shengyu Zhou, Hu Duan, Te Liang, Haoyu Wang, Yanrong Wang, Shiyu Jiang, Fengyi Zhao, Qiaofeng Zhong, Yu Zhou, Shasha Wang, Jiayu Dai, Jiarui Yao, Di Wu, Zhishang Zhang, Yan Sun, Xiaohong Han, Xiaobo Yu, Yuankai Shi
Abstract
: This study provides the first evidence that AAb biomarkers selected using high-throughput protein microarrays can predict anti-PD1 therapeutic response and guide anti-PD1 therapy.
Topics & Concepts
MedicineLung cancerOncologyInternal medicineAutoantibodyLymphomaCohortImmunologyAntibodyImmunotherapy and Immune ResponsesMonoclonal and Polyclonal Antibodies ResearchCancer Immunotherapy and Biomarkers