The emerging role of immunotherapy for the treatment of sarcoma
Nicholas D. Klemen, Ciara M. Kelly, Edmund K. Bartlett
Abstract
Clinicians caring for patients with sarcoma founded the field of cancer immunotherapy. Despite this, contemporary success with immunotherapy for sarcoma has been limited. Here, we review immunotherapy for sarcoma including Coley's toxins, interleukin-2, adoptive cell transfer, and checkpoint blockade. We detail recent and ongoing efforts to combine checkpoint blockade with other immune modulators, surgery, or radiation. These results, along with ongoing investigations, have identified immunotherapeutic approaches as a promising avenue for progress in advanced sarcomas.
Topics & Concepts
MedicineImmunotherapySarcomaBlockadeAdoptive immunotherapyImmune checkpointCancer immunotherapyCancerInternal medicinePathologyReceptorCAR-T cell therapy researchImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers