Heterometallic ruthenium–osmium complexes: dual photodynamic and photothermal therapy for melanoma and drug-resistant lung tumour<i>in vivo</i>
Yu‐Ang Deng, Shi‐Jie Tang, Mengfan Wang, Xiaoxia Ren, Xuelian Li, Lizhen Zeng, Dan‐ni Ren, Meng‐Ru Wang, Wei‐Lie Xiao, Zhongyan Cai, Dan Zhang, Hongbin Zhang, Feng Gao
Abstract
A hetero-dinuclear Ru–Os complex can entirely eradicate PDT-resistant melanoma and cisplatin-resistant non-small cell lung tumors by dual PDT/PTT under an 808 nm low-power laser. It also has low hepatorenal toxicity and low metal residue in mice.
Topics & Concepts
In vivoMelanomaRutheniumPhotodynamic therapyOsmiumCancer researchChemistryPhotothermal therapyMedicineMaterials scienceBiologyNanotechnologyBiochemistryCatalysisBiotechnologyOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesClick Chemistry and Applications