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Design and synthesis of novel benzothiophene analogs as selective estrogen receptor covalent antagonists against breast cancer

Chengfeng Bai, Shengnan Ren, Shuangjie Wu, Meiqi Zhu, Guoshun Luo, Hua Xiang

2021European Journal of Medicinal Chemistry19 citationsDOI

Topics & Concepts

Selective estrogen receptor modulatorTamoxifenEstrogen receptorChemistryBenzothiophenePharmacologyRaloxifeneBreast cancerCancer researchEstrogenEstrogen receptor alphaEstrogen receptor betaCancerInternal medicineMedicineThiopheneOrganic chemistryEstrogen and related hormone effectsClick Chemistry and ApplicationsSynthesis and biological activity
Design and synthesis of novel benzothiophene analogs as selective estrogen receptor covalent antagonists against breast cancer | Litcius