ADME profiling, molecular docking, DFT, and MEP analysis reveal cissamaline, cissamanine, and cissamdine from <i>Cissampelos capensis</i> L.f. as potential anti-Alzheimer's agents
Maram B. Alhawarri, Mohammad G. Al‐Thiabat, Amit Dubey, Aisha Tufail, Dania Fouad, Bilal Harieth Alrimawi, Mohamad Dayoob
Abstract
studies are necessary to validate these theoretical predictions and to understand the precise mechanisms through which these alkaloids may exert their therapeutic effects.
Topics & Concepts
ADMEChemistryContext (archaeology)In silicoDocking (animal)Computational biologyBiologyBiochemistryMedicineIn vitroGenePaleontologyNursingSynthesis and bioactivity of alkaloidsTraditional and Medicinal Uses of AnnonaceaeDrug Transport and Resistance Mechanisms