Engineered Biomimetic Membranes for Organ-on-a-Chip
Maedeh Rahimnejad, Fariba Rasouli, Sepideh Jahangiri, Sepideh Ahmadi, Navid Rabiee, Marzieh Ramezani Farani, Omid Akhavan, Mohsen Asadnia, Yousef Fatahi, Sang‐Hoon Hong, Jung‐Ho Lee, Junmin Lee, Sei Kwang Hahn
Abstract
Organ-on-a-chip (OOC) systems are engineered nanobiosystems to mimic the physiochemical environment of a specific organ in the body. Among various components of OOC systems, biomimetic membranes have been regarded as one of the most important key components to develop controllable biomimetic bioanalysis systems. Here, we review the preparation and characterization of biomimetic membranes in comparison with the features of the extracellular matrix. After that, we review and discuss the latest applications of engineered biomimetic membranes to fabricate various organs on a chip, such as liver, kidney, intestine, lung, skin, heart, vasculature and blood vessels, brain, and multiorgans with perspectives for further biomedical applications.