Sulfonyl hydrazide induced sulfenylation of imidazoheteroarenes: A ‘catalyst and solvent free’ protocol
Sourav Mal, Manoranjan Jana
Abstract
A simple and hassle free sustainable protocol for the sulfenylation of imidazoheterocycles has been developed. Sulfonyl hydrazides have been used as the generator of active thio carrier in situ in the form of “sulfono thionate” under neat condition to produce the desired sulfenylated imidazoheterocycles in good to excellent yields. The new methodology does not demand the requirement of any solvent or catalyst by simply regulating the proportion of reactants. Thus, the methodology is greener and easy to handle.
Topics & Concepts
ChemistrySulfonylCatalysisHydrazideProtocol (science)SolventThio-Combinatorial chemistryOrganic chemistryReaction conditionsAlternative medicinePathologyMedicineAlkylSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsSynthesis and Catalytic Reactions