The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal Cancer
Patrycja Kłos, Siarhei A. Dabravolski
Abstract
Inflammatory bowel disease (IBD) is one of the leading gut chronic inflammation disorders, especially prevalent in Western countries. Recent research suggests that mitochondria play a crucial role in IBD development and progression to the more severe disease-colorectal cancer (CRC). In this review, we focus on the role of mitochondrial mutations and dysfunctions in IBD and CRC. In addition, main mitochondria-related molecular pathways involved in IBD to CRC transition are discussed. Additionally, recent publications dedicated to mitochondria-targeted therapeutic approaches to cure IBD and prevent CRC progression are discussed.
Topics & Concepts
Inflammatory bowel diseaseColorectal cancerMitochondrionMedicineDiseaseInflammationCancerInflammatory Bowel DiseasesMouse model of colorectal and intestinal cancerBioinformaticsImmunologyCancer researchBiologyInternal medicineGeneticsTuberculosis Research and EpidemiologyInflammatory Bowel DiseaseDrug Transport and Resistance Mechanisms